Sep 3, ABC transporters have been well investigated for mammals. For fish and their embryos, however, little is known about such transporters. New Mode of Bacteria Dispersal · Android Child's Face Strikingly . Luckenbach: "Many effects of substance mixtures may be explained on Dating with Hepatitis C. The cleanness from crossover petition vice the clutch publicized many to many fish dating abc transporters from microorganisms to many fish dating thyrax. As many ABC genes are involved in human genetic diseases, and important drug The ATP-binding cassette (ABC)1 transporters constitute one of the largest Recent reviews have provided overviews of ABC proteins in bacteria  and of one-to-one orthologous relationships between mammalian and fish genes.
SerLys in one of the four families. Expression analysis in human skin and mutagenesis interrogation in zebrafish confirmed the functional role of ABCB6 in melanocytes and pigmentation. Conclusion Our study has advanced our understanding of DUH pathogenesis and revealed the shared pathological mechanism between pigmentary DUH and ocular coloboma.
ABC transporters act to transport compounds across cellular membranes and are involved in a diverse range of biological processes. Thus, the applicability to biotechnology is vast, including cancer resistance in humans, drug resistance among vertebrates, and herbicide and other xenobiotic resistance in plants.
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In addition, plants appear to harbor the highest diversity of ABC transporter genes compared with any other group of organisms. This study applied transcriptome analysis to survey the kingdom-wide ABC transporter diversity in plants and suggest biotechnology applications of this diversity.
We utilized sequence similarity-based informatics techniques to infer the identity of ABC transporter gene candidates from phylogenetically-diverse plant transcriptomes. As expected, simpler organisms, such as algae, had fewer unique members than vascular land plants.
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Differences were also noted in the richness of certain ABC transporter subfamilies. We present a transcriptomic overview of ABC transporter gene members across all major plant groups. This article has been cited by other articles in PMC. Associated Data Figure S1: Functional domain organizations of catfish ABC transporters. Gene names and accessions of reference ABC transporters used in this study.
XLSX Abstract Background Although a large set of full-length transcripts was recently assembled in catfish, annotation of large gene families, especially those with duplications, is still a great challenge. Most often, complexities in annotation cause mis-identification and thereby much confusion in the scientific literature. The ATP-binding cassette ABC transporter gene superfamily is a large gene family that encodes membrane proteins that transport a diverse set of substrates across membranes, playing important roles in protecting organisms from diverse environment.
Most ABC transporters are conserved among vertebrates, though cases of recent gene duplications and gene losses do exist. The establishment of orthologies should allow functional inferences with the information from model species, though the function of lineage-specific genes can be distinct because of specific living environment with different selection pressure.
Introduction Fish are exposed to numerous toxicants present in the aquatic environment. Catfish, as a bottom-dwelling fish species, is highly adaptable to its associated aquatic environment such as low dissolved oxygen, high level of toxins e.
Therefore, catfish can serve as a good research model for toxicological studies. Numerous genomic resources have been developed to study detoxification-related genes in catfish, including a large number of ESTs draft whole genome sequences unpublishedand RNA-Seq transcriptome assemblies  — .
We recently assembled a comprehensive transcriptome and generated over 14, full-length transcripts by RNA-Seq of a doubled-haploid channel catfish . Such full-length transcripts allowed genome-wide identification and annotation of gene families in catfish.